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Collawell Collagen Research On Skin Health

Collagen has been widely used in cosmetic surgery. Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging.[1]

Collagen is the building block for the skin[2]. Collagen ensures the cohesion, elasticity and regeneration of skin.  Skin tissue is composed of various molecules, some of which are amino acids, and these amino acids are essential for maintaining an even skin structure and thus healthy skin. . Maintaining the amount of collagen is the key to beautiful skin.  Glycine, proline, alanine and hydroxyproline are the main constituents of collagen; replenishing these constituent amino acids appears to be needed to maintain the amount of collagen at healthy levels.

Maintaining good skin care  is a continuos process.  Healthy nutrition and adequate fluids are helpful and can improve the youthful, healthy appearance of skin.  Consuming  the right amount of collagen can be beneficial to beautiful skin.  Collagen’s content of the amino acids glycine, proline, alanine and hydroxyproline is needed to maintain the amount of collagen at healthy levels and thus reduce the signs of skin aging.

There is many research  showing nutraceuticals can contribute to healthy skin [3].  The use of topical creams and cosmetic products can affect skin condition from outside, however, nutritional supplements taken orally will also have an impact from within the skin. A number of clinical research has shown that Collagen, a natural protein can :

  • Promotes younger looking skin
  • Improves skin moisture level
  • Improves the signs of deep wrinkles
  • Improves skin suppleness

Some notable clinical studies on Collagen for skin health.

Twenty healthy Japanese women consumed a drink containing 10g of collagen hydrolysate or placebo every day for 2 months. At 1 month, collagen-ingested group showed a much greater increase than placebo group in water absorbing capacity of the outermost layer of the skin. The difference became larger when the test period was extended to 2 months [4].

A study published in The Journal of the American Nutraceutical Association, a total of 40 women aged 35-65 years were enrolled in a blinded, randomized, parallel design of eight-week, four-visit study to assess the safety and efficacy of dietary collagen hydrolysate formulation for the improvement of age-related degenerative skin changes. It was reported that the consumption of the dietary collagen hydrolysate formulation resulted in a highly statistically significant improvement in periorbital (eyelid) wrinkling (crow’s feet) and periorbital aging, as well as overall facial aging with minimal adverse effects [5].

A clinical study proving the effect of collagen hydrolysate on skin elasticity has been published [6]. In a double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of collagen hydrolysate product or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin biophysical parameters related to cutaneous aging such as skin elasticity (primary interest), skin moisture, trans-epidermal water loss and skin roughness (secondary interest) were objectively measured immediately before starting the product treatment, after 4 and 8 weeks of daily intake.

At the end of the study, skin elasticity in both collagen hydrolysate dosage groups showed a statistically significant improvement as compared to placebo. At 4 weeks after the last product intake, the treatment subgroup of elderly women still showed statistically higher skin elasticity levels than the placebo group, with about 98% of the positive effect on this parameter after having stopped collagen hydrolysate intake [6].

The results clearly demonstrated that the oral consumption of collagen hydrolysate led to a statistically significant improvement in skin elasticity. No visible changes detected on the skin roughness.. Researchers concluded that the positive impact of oral intake of collagen hydrolysate on skin health seems to be long-lasting, especially in elderly women aged over 50 years, in contrast to most topically applied collagen product [6]

The above clinical studies verify that regular intake of collagen improves the basic skin condition and structure. Studies have shown that taking collagen peptides showed a significant improvement in skin elasticity and skin moisture. [7]


References:
  1. Dermal Fillers | The Ageing Skin. Pharmaxchange.info. Retrieved on    2013-04-21. http://pharmaxchange.info/press/
  2. Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 22.3, Collagen: The Fibrous Proteins of the Matrix.
  3. Cosgrove, M.C., Franco, O.H., Granger, S.P., Murray, P.G. and Mayes, A.E. 2007. Dietary nutrient intakes and skin-aging appearance among middle-aged American women.The American Journal of Clinical Nutrition, 86: 1225-1231.
  4. Sumida, E, Hirota, A, & Kuwaba, K. (2004). The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood. Journal of Nutrition & Food Sciences, 7, 45-52.
  5. Kantor, I. et al. (2002). Results of a study evaluating the use of a dietary supplement formula in the management of age-related skin changes in women with moderate to severe wrinkling of the periorbital area. The Journal of the American Nutraceutical Association, 5(2).
  6. Proksch, E. et al. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacology and Physiology, 27, 47-55. doi: 10.1159/000351376
  7. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.Skin Pharmacol Physiol.